Great Lakes

Although lakes often have names like "This Lake" and "That Lake", the Great Lakes are named the other way around as "Lake This" and "Lake That". Listed West-to-East (with rank on Wikipedia's list of the world's largest lakes by volume of water in brackets), they are:

• Lake Superior (3rd) - the largest and westernmost lake, sometimes said to have the shape of a wolf's head, largest lake on Earth by surface area
• Lake Michigan (6th) - the only Great Lake located entirely in the U.S., a long narrow body of water plunging south
• Lake Huron (7th) - including Georgian Bay, almost a separate lake, on the east side
• Lake Erie (17th) - the southernmost lake
• Lake Ontario (11th) - the easternmost

The American-Canadian border runs more-or-less down the middle of lakes Huron, Erie and Ontario. The border also runs across Lake Superior, but most of that lake is in the US; the border is just north of Isle Royale National Park, the big island on the west side. Lake Michigan is entirely in the US, Georgian Bay entirely in Canada.
The border between Michigan on the east and Wisconsin and Illinois on the west runs down the middle of Lake Michigan.
The Great Lakes themselves are not the only waterways in the system. Others include:

• The Saint Mary's River between Lakes Superior and Huron
• The Straits of Mackinac between Lakes Michigan and Huron
• Several bodies of water between Southeast Michigan and Southwestern Ontario

The Niagara River (with its famous falls) between Lakes Erie and Ontario; ship traffic bypasses the falls via the Welland Canal

The Saint Lawrence which drains the whole system into the Atlantic Ocean

The border runs through most of these as well, though it only follows the Saint Lawrence for a short distance; further east, both sides of the river are in Québec and the border is further south, following the 45th parallel across northern Vermont.

The following regions lie around the Great Lakes.

The following cities lie on or close to the shores of the Great Lakes.

Canada

• , Ontario
• , Ontario
• , Ontario

United States

By body of water

Broken down according to the bodies of water they are on, and in upstream-to-downstream order, some important places are:

• Lake Superior

• Duluth, Minnesota
• Thunder Bay, Ontario

Lake Michigan

• Chicago
• Milwaukee

Lake Huron

• Sarnia-Port Huron

Detroit River, between lakes Huron and Erie

• Detroit
• Windsor, Ontario

Lake Erie

• Cleveland
• Buffalo

Niagara River, between lakes Erie and Ontario

• Niagara Falls, two cities on either side of the border

Lake Ontario

• The Golden Horseshoe, including Toronto, Hamilton, and the suburbs in between
• Rochester
• Kingston, Ontario

Downstream along the Saint Lawrence

The region is well provided with recreational areas; in roughly west-to-east order, some of the main ones are:

• , a large island on the west side of Lake Superior, in the US but near the border
• , in the Straits of Mackinac between Lakes Michigan and Huron
• , on the northeast shore of Lake Michigan some distance from the big cities
• at the southern tip of Lake Michigan
• , popular as "cottage country" for Toronto and nearby areas, part of Lake Huron
• , a peninsula into Lake Erie which is the southernmost point in Canada, at roughly the latitude of Chicago or Beijing
• , a major amusement park in Ohio, on Lake Erie
• , on the US side near several Ohio cities
• , toward the east end of Lake Ontario, on the Canadian side
• , downstream in the Saint Lawrence

Some of these are quite developed and others still close to wilderness.

The Great Lakes cover a vast region, so there are naturally many points of entry, preeminent among which is Chicago's busy O'Hare International Airport. Other major airports, in order starting from the busiest: Detroit Metropolitan, Toronto Pearson International, Minneapolis-St. Paul International, Chicago Midway, and Cleveland-Hopkins International.
The principal highways of the Great Lakes on the U.S. side of the border are I-90, which runs east-west along the south coasts, and I-94, which runs a more eccentric course from the west coast of Lake Michigan, through Chicago, central Michigan, Detroit and Port Huron where it then passes across the river to Sarnia, Ontario. On the Canadian side, Highway 401 runs west-east from Windsor-Detroit through Toronto and on to Kingston and Montreal. The Trans-Canada Highway traces the northern shores of Lake Huron and Lake Superior.

The Great Lakes boast some of the world's great urban skylines, and their crystal blue waters also provide anyone with a boat the means to take in a grand view of them. Chicago, the birthplace of the skyscraper, has a claim to be the greatest, but it's a hard claim to stake in a region with skylines such as those of Toronto and Detroit, and to a lesser extent Milwaukee, Cleveland, Hamilton, Buffalo, and Rochester.
Natural destinations abound along the region's lakeshores. The Indiana Dunes, and Sleeping Bear Dunes, and Pictured Rocks National Lakeshore provide the most striking lakeside landscapes, while island destinations like the Thousand Islands, Isle Royale National Park, St. Joseph Island, the Lake Erie Islands, and Manitoulin Island make for natural vacation destinations.
Major attractions right on the water are similarly in large supply. Chicago's Navy Pier on Lake Michigan is one of the most visited attractions in the Midwest for its amusement park, live entertainment, shops, restaurants, and theater. Toronto's CN Tower on Lake Ontario is the tallest free-standing structure in the Western Hemisphere, providing tourists with great views, including one very steep one down from the glass floor. Cedar Point Amusement Park near Sandusky, Ohio, has been voted best amusement park in the world for at least a decade by Amusement Today. Perhaps the best known to the world, though, is massive Niagara Falls.

Many boaters use the Great Lakes, St. Lawrence Seaway and their connection points as a travel route. There are many marinas and public boat ramps available for this purpose, and the lakes and connected waterways such as the Erie Canal and Rideau Canal are popular with people cruising on their own or chartered boats. Also, the Victory Cruise Lines, Great Lakes Cruising Company Pearl Seas Cruises and the Blount Small Ship Adventures provide cruise ships on the Great Lakes. Cruise Season typically runs from May through October.

Great Lakes beaches are something most of the world has overlooked. While yes, for much of the year, it's too cold to swim, there are some fantastic beaches that are usable in the summer months. The lakes are big enough to make you feel like you are at the ocean, with waves to boot, but without the annoying salt and jellyfish. And throughout much of the water system, the water is actually clean enough to drink (not recommended) and certainly clear enough where you can freely open your eyes underwater. Some of the most famous beaches include the Great Lakes' longest at Wasaga Beach in Central Ontario, the beach volleyball hub of the Midwest at Lincoln Park Beach in Chicago, the beautiful beaches along the Indiana Dunes National Park, and the affluent beach communities along Chicago's version of the Hamptons in Harbor Country, Michigan. And even when it's too cold for swimming, several beaches throughout the region are actually known for surfing.
In this area, if someone says something like "let's go to the Lake" without naming it, they're probably referring to the nearest Great one.

There isn't any one sort of souvenir or good associated with the Great Lakes (aside, perhaps, from Detroit automobiles or Milwaukee beer), but there are plenty of great places to go shopping. Chicago's Magnificent Mile is renowned as one of the world's truly great retail strips. Yorkville serves much the same purpose in Toronto. A smaller retail location is in Detroit's Renaissance Center, which is probably worth a visit regardless of whether you want to shop at its many stores and souvenir shops. Tower City Center in Cleveland is another major shopping complex, with retail running the gamut from high end boutiques to low-end national franchises and back again.

What could possibly unite the disparate culinary regions of the Great Lakes? Oh right, fish. Lake trout, wild salmon, chubs, smelt, perch, walleye, and whitefish are all very popular both among recreational and commercial fishers throughout the region. Smoked fish and shrimp is especially popular in small "shacks," particularly along the industrial shores of southwestern Lake Michigan, and you should jump at the chance to try some.
Similarities end at fish, however. The Chicagoland area is a culinary delight, from high end contemporary American in Chicago, to low end regional fast food like Chicago-style pizza, hot dogs, etc., and cuisines brought their via the tides of immigration from the American South, Greece, Middle East, Mexico, Vietnam, etc. Toronto rivals Chicago for international cuisine, both high and low end, with enormous immigrant populations from all over Asia especially.

There is one city in this region synonymous with drinking, and that is Milwaukee. Brew City was for a long time the world's leading beer producer, and remains firmly associated with the drink both in the popular culture ideal and the reality of the city's great nightlife. While none can rival that of Milwaukee, the cities and towns lining the Great Lakes largely share its affection for the drink, particularly in can form, accompanied with cheap shots of liquor.
High end nightlife in the Great Lakes congregates in both Chicago and Toronto. Live music, however, is much more widespread, with vibrant independent music scenes throughout all the major cities, especially in Chicago and Detroit.

Where next? Perhaps the obvious choice would be to head deeper into the Midwest, perhaps down the Mississippi River towards St. Louis, Memphis, and New Orleans, up the Mississippi through the Twin Cities (Minneapolis and Saint Paul) to the river’s source in the North Woods of Itasca State Park, or down through the cornfields to Indianapolis.
Following the waterways east takes you along the St. Lawrence River through the Thousand Islands and towards Montreal, Quebec City, and on to Canada's Atlantic Provinces. Or you could turn south from the St. Lawrence towards Lake Champlain to get to Lake George and the Adirondacks.
Keep following I-90 west to get deep into the American Interior. It will eventually take you into the Black Hills and Badlands region of South Dakota, home to Mount Rushmore (and a lot of bison), and on to Wyoming.
On the Canadian side, the Trans-Canada Highway leads west along the north shore of lakes Huron and Superior as far as Thunder Bay, then on to Winnipeg and Canada's Prairie Provinces. Much of that route is through quite lightly populated areas; what you see will be mostly trees and lakes with the occasional moose. Those more interested in cities may prefer to cross into the US and take a route that runs south of the lakes.